Immunosuppressive Agents A Family Of Medications
Meet The Family.....
Antilymphocyte Globulins (ATG)
Azathioprine
Azathioprine Reduced Allograft Rejection & Allowed Patients To Lead Relatively A Normal Life.
Mechanism Of Action
Prevents Mitotic Division
Medical Uses
Rheumatoid Arthritis
Azathioprine Adverse Side Effects
Pancreatitis
Viral Infections
Cyclosporine (Sandimmune)
Cyclosporine Mechanism Of Action
Inhibits The CD4+ Cells From Secreting The Lymphokine Called Interleukin-2 (IL-2)
Cyclosporine Adverse Side Effects
Also.........
Acne
Dermatological Disorders
Corticosteroids
Corticosteroids Mechanisms Of Action
Blocks The Activation Of T8+ Killer Cells
Corticosteroids Medical Uses
Corticosteroids Adverse Side Effects
Redistribution Of Fat To Trunk
Antilymphocyte Globulins
ATG & ALG Are Purified Immunoglobulins Prepared Commercially From Hyperimmune Serum In Horses, Sheep, Rabbits, & Goats Following Immunization With Human T Lymphocytes
These Antibodies Knock Out The CD4+ Cells (T Cells) That Would Otherwise Attack The Allograft
Adverse Side Effects
Infections
Muromonab-CD3 Monoclonal Antibody
Produced By The Fusion Of Mouse Antibody Producing Cells With Plasmacytoma Cells - A Combination That Creates A Hybridoma That Vigorously Makes High Quality Antibodies
OKT3 Causes The Rapid Clearance Of CD4+ Cells From The Circulation
Functionally, What Does This Mean ?
Vincristin (Oncovin)
Vincristin Causes Meta-Phase Arrest By Binding Tubulin - The Cellular Protein Which Helps Separate The Chromosomes Into The Dividing Daughter Cells
Vincristin Is Used To Arrest The Clonal Expansion Of CD4+ Cells - Thus An Attack On Transplanted Tissue Cannot Be Mounted
Methotrexate (Folex)
It Inhibits The Cellular Use Of Folic Acid - A Metabolite Necessary For Nucleic Acid Synthesis
Clinical Considerations
Do Not Fatigue The Patient
Email: David.Arnall@NAU.EDU , DAArnall@AOL.COM
Home Page: http://jan.ucc.nau.edu/~daa/pt675/
Download presentation source