The Antihyperlipidemic Medications
Carried in the blood to fat depots and transported across the vasculature with the help of Capillary-Bound LPL
Very Low Density Lipoproteins (VLDL)
Cholesterol containing particle
Low Density Lipoprotein (LDL)
In the liver LDL is recycled for its cholesterol content
High Density Lipoprotein (HDL)
Types of hyperlipoproteinemias
Type IIa - Essential Familial Variety
Type IIb - Familial Combined Variety
Type IV - Endogenous Hypertriglyceridemia
The Antihyperlipidemic Drugs
HMG-CoA Reductase Inhibitors
Mechanism Of Action
There is a compensatory drop in plasma LDL due to the up-regulation of the LDL receptor and enhanced clearance of LDL from the plasma
These medications may lower the cholesterol content of the VLDL particle such that when VLDL disposes of its TGs becoming LDL, there is an enhanced attraction for the cholesterol poor LDL particle and its receptor - greater LDL clearance
Adverse Side Effects
Medical Uses
The Fibric Acids
Mechanisms of Action
Decrease the synthesis of cholesterol
Gall stone formation
Bile Acid Binding Resins
Mechanism of Action
The net effect - causes the liver to scavenge more cholesterol from the body to make additional bile salts
Nicotinic Acid
Inhibits the destruction of HDL thus allowing a permissive rise in HDL
Email: David.Arnall@NAU.EDU , DAArnall@AOL.COM
Home Page: http://jan.ucc.nau.edu/~daa/pt675/
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