Glucoregulatory Drugs
Classification Of Diabetic Patients
Type I Diabetes Mellitus
Type II Diabetic Patient
Problem :
Exhibit Peripheral Tissue Resistance To Insulin
Drug Choices For The Diabetic Patient
Insulin
The Sulfonylureas
Sulfonylureas
Second Generation Drugs
Sulfonylureas Mechanism Of Action
Increase The Sensitivity of Peripheral Tissues To Insulin
Medical Uses Of The Sulfonylureas
The Overall Effect :
Adverse Side Effects For The Sulfonylureas
The Biguanides
Biguanides Mechanism Of Action
Suppress Gluconeogenesis In The Liver
Stimulate Glycolysis
Medical Uses Of The Biguanides
Help To Deplete Blood Levels Of Glucose By Reducing Uptake Of Dietary Glucose
Adverse Reactions For The Biguanides
Alpha-Glucosidase Inhibitors
Mechanism Of Action For AGI’s
The Alpha-Glucosidase Inhibitors do not increase insulin receptor sensitivity and do not increase blood insulin levels in Type II diabetics.
Medical Uses Of AGI’s
Adverse Side Effects Of AGI’s
Others
Repaglinide Mechanism of Action
Adverse Reactions
Medical Uses
Troglitazone
Mechanism Of Action
Decreases liver glucose output
Adverse Side Effects
The Insulins
Porcine, Bovine, Humulin
Intermediate Acting : 12-20 Hrs
Adverse Reactions Hypoglycemia
Headaches
Lipodystrophy
Clinical Considerations
Make Sure The Patient Is Hydrated
Exercise Considerations
Type II Diabetic
Blood Glucose
Eat extra CHO during exercise if longer than 30 minutes
Inject Insulin Into Skinfold of Non-Exercising Muscle (Abdominal Wall)
Carry Money While Exercising
Email: David.Arnall@NAU.EDU , DAArnall@AOL.COM
Home Page: http://jan.ucc.nau.edu/~daa/pt675/
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