The Anticonvulsants

2/15/99


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Table of Contents

The Anticonvulsants

Seizure Classification

Complex Partial Seizure

Partial Become Generalized

Generalized Seizures

No confused state after seizure

Myoclonic Seizures

Clonic Seizures

Tonic Seizures

Tonic-Clonic Seizures (Grand Mal)

Atonic Seizures

Anticonvulsants …A Plethora Of Drugs

The Hydantoins

Phenytoin (Dilantin) - Prototypic Drug

Dilantin - Mechanism of Action

Hydantoins - Adverse Side Effects

The Barbiturates

Mechanism Of Action

Reduces neurotransmitter release thereby quieting the brain

Adverse Side Effects

The Iminostilbenes

Mechanism of Action

Adverse Side Effects

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Succinimides

Mechanism of Action

Adverse Side Effects

Aplastic Anemia

Renal and hepatic toxicity

Stevens-Johnson Disease

Necrotic vasculitis may be present (capillary damage)

Cause ????

Benzodiazepines

Mechanism of Action

Adverse Side Effects

Valproic Acids

Mechanism of Action

Anticonvulsants - Medical Uses

Tegretol

Clinical Considerations

Are there any external triggers which could set off the seizure ??? (light, sound, fatigue, odors)

Are the patients under unusual stress - divorce, family deaths, etc.

Have a good seizure plan in the clinic

Author: Microsoft Corporation

Email: David.Arnall@NAU.EDU , DAArnall@AOL.COM

Home Page: http://jan.ucc.nau.edu/~daa/pt675/

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