| Type | Names | Examples | Reaction Time | Antibodies
Involved |
Action |
| Type I | Anaphylactic
Allergy |
Insect stings, hay fever, asthma, food allergy, immediate hypers | Immediate, within 20 minutes | IgE | IgE antibodies link mast cells and allergen |
| Type II | Cytotoxic | Transfusion reaction, RH disease of the newborn, Graves' disease | Variable | IgG, IgM | IgG and IgM mark normal human cells as targets for immune destruction |
| Type III | Immune-complex | Systemic lupus erythemathosus, rheumatoid arthritis, serum sickness | Variable | IgG | Antigen-antibody complexes are distributed throughout the body |
| Type IV | Cell mediated
Delayed hypers. |
Organ transplantation rejection, poison ivy/oak, clothing and jewelry allergies, granulomatous reaction | 12 hours to several weeks | None | Lymphokines and macrophages interact, causing inflammation |
Type
Damage caused by
antibody action
| Type I | Mast cells and basophils release chemicals (histamine) during degranulation |
| Type II | Complement and phagocytosis |
| Type III | Complement and neutrophils stimulated by antigen-antibody complexes |
| Type IV | T cells activated |